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TRM3 / TARBP1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q13395 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 182kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 6894 |
|---|---|
| Other Names | Probable methyltransferase TARBP1, 2.1.1.-, TAR RNA-binding protein 1, TAR RNA-binding protein of 185 kDa, TRP-185, TARBP1, TRM3, TRP185 |
| Target/Specificity | 17 amino acid peptide from near the center of human TRBP1. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | TRM3 / TARBP1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TARBP1 |
|---|---|
| Synonyms | TRM3, TRP185 |
| Function | Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.
References
Wu-Baer F.,et al.EMBO J. 14:5995-6009(1995).
Gregory S.G.,et al.Nature 441:315-321(2006).
Wu-Baer F.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:7153-7157(1995).
Wu-Baer F.,et al.J. Biol. Chem. 271:4201-4208(1996).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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