|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (2, 2.5 µg/ml), WB (1 µg/ml),|
|Other Names||Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein 14, FGF-inducible 14, Tweak-receptor, TweakR, CD266, TNFRSF12A, FN14|
|Target/Specificity||human IgG1 Fc-tagged Fn14 protein|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TNFRSF12A / FN14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas|
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Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Feng S.-L.Y.,et al.Am. J. Pathol. 156:1253-1261(2000).
Tanaka S.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Wiley S.R.,et al.Immunity 15:837-846(2001).
He F.,et al.Protein Sci. 18:650-656(2009).
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