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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRAF3 Antibody (C-Terminus)   

TRAF3 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - TRAF3 Antibody (C-Terminus) ALS11499
    Immunofluorescence of TRAF3 in 3T3 cells with TRAF3 antibody at 2 ug/ml.
  • IHC - TRAF3 Antibody (C-Terminus) ALS11499
    Anti-TRAF3 antibody IHC of human brain.
  • IHC - TRAF3 Antibody (C-Terminus) ALS11499
    Anti-TRAF3 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q13114
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 64kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 7187
Other Names TNF receptor-associated factor 3, 6.3.2.-, CAP-1, CD40 receptor-associated factor 1, CRAF1, CD40-binding protein, CD40BP, LMP1-associated protein 1, LAP1, TRAF3, CAP1, CRAF1
Target/Specificity 16 amino acid peptide from near the carboxy terminus of human TRAF3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsTRAF3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRAF3
Synonyms CAP1, CRAF1
Function Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Cellular Location Cytoplasm. Endosome. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.
Research Areas
Citations (0)

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Background

Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

References

Hu H.M.,et al.J. Biol. Chem. 269:30069-30072(1994).
Mosialos G.,et al.Cell 80:389-399(1995).
Sato T.,et al.FEBS Lett. 358:113-118(1995).
Cheng G.,et al.Science 267:1494-1498(1995).
Li W.B.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11499
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