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GB5 / GNB5 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - GB5 / GNB5 Antibody ALS11510
    Anti-GNB5 antibody IHC of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O14775
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 44kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 10681
Other Names Guanine nucleotide-binding protein subunit beta-5, Gbeta5, Transducin beta chain 5, GNB5
Target/Specificity Peptide from the D1 blade of GNB5 protein.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsGB5 / GNB5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNB5
Function Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (PubMed:27677260). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity).
Cellular Location Membrane {ECO:0000250|UniProtKB:P62881}.
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

References

Jones P.G.,et al.Biochim. Biophys. Acta 1402:288-291(1998).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 467.50
Cat# ALS11510
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