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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BCL10 / BCL-10 Antibody (N-Terminus)   

BCL10 / BCL-10 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - BCL10 / BCL-10 Antibody (N-Terminus) ALS11529
    Immunocytochemistry of Bcl10 in Raji cells with Bcl10 antibody at 1 ug/ml.
  • IF - BCL10 / BCL-10 Antibody (N-Terminus) ALS11529
    Immunofluorescence of Bcl-10 in Raji cells with Bcl-10 antibody at 10 ug/ml.
  • IHC - BCL10 / BCL-10 Antibody (N-Terminus) ALS11529
    Anti-BCL10 antibody IHC of human breast.
  • IHC - BCL10 / BCL-10 Antibody (N-Terminus) ALS11529
    Anti-BCL10 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession O95999
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 26kDa
Dilution IHC-P (5 µg/ml), WB (1:500),
Additional Information
Gene ID 8915
Other Names B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10, BCL10, CIPER, CLAP
Target/Specificity peptide corresponding to amino acids near the amino terminus of human Bcl10
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBCL10 / BCL-10 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL10
Synonyms CIPER, CLAP
Function Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Cellular Location Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

References

Willis T.G.,et al.Cell 96:35-45(1999).
Koseki T.,et al.J. Biol. Chem. 274:9955-9961(1999).
Thome M.,et al.J. Biol. Chem. 274:9962-9968(1999).
Yan M.,et al.J. Biol. Chem. 274:10287-10292(1999).
Srinivasula S.M.,et al.J. Biol. Chem. 274:17946-17954(1999).

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$ 395.00
Cat# ALS11529
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