MAP4K4 Antibody (aa931-947)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | O95819 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 142kDa |
Dilution | IHC-P (20 µg/ml) |
Gene ID | 9448 |
---|---|
Other Names | Mitogen-activated protein kinase kinase kinase kinase 4, 2.7.11.1, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, MAP4K4, HGK, KIAA0687, NIK |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | MAP4K4 Antibody (aa931-947) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAP4K4 |
---|---|
Synonyms | HGK, KIAA0687, NIK |
Function | Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr- 322. |
Cellular Location | Cytoplasm. |
Tissue Location | Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
References
Yao Z.,et al.J. Biol. Chem. 274:2118-2125(1999).
Wright J.H.,et al.Mol. Cell. Biol. 23:2068-2082(2003).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Saito T.,et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
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