|Application ||WB, IHC-P|
|Dilution||IHC-P (20 µg/ml)|
|Other Names||Mitogen-activated protein kinase kinase kinase kinase 4, 220.127.116.11, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, MAP4K4, HGK, KIAA0687, NIK|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||MAP4K4 Antibody (aa931-947) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HGK, KIAA0687, NIK|
|Function||Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.|
|Tissue Location||Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
Yao Z.,et al.J. Biol. Chem. 274:2118-2125(1999).
Wright J.H.,et al.Mol. Cell. Biol. 23:2068-2082(2003).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Saito T.,et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
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