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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P30153 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 5518 |
|---|---|
| Other Names | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha, PPP2R1A |
| Target/Specificity | Amino acids 7-19 of PPP2R1B |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | PPP2R1A Antibody (aa7-19) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPP2R1A |
|---|---|
| Function | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. |
| Cellular Location | Cytoplasm. Chromosome, centromere. Note=Centromeric localization requires the presence of BUB1 |
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Provided below are standard protocols that you may find useful for product applications.
Background
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
References
Walter G.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:8669-8672(1989).
Hemmings B.A.,et al.Biochemistry 29:3166-3173(1990).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Lubec G.,et al.Submitted (MAR-2007) to UniProtKB.
Zolnierowicz S.,et al.Biochem. J. 317:187-194(1996).
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