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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   TICAM1 / TRIF Antibody (C-Terminus)   

TICAM1 / TRIF Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - TICAM1 / TRIF Antibody (C-Terminus) ALS11554
    Anti-TICAM1 / TRIF antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8IUC6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 76kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 148022
Other Names TIR domain-containing adapter molecule 1, TICAM-1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, MyD88-3, TIR domain-containing adapter protein inducing IFN-beta, TICAM1, PRVTIRB, TRIF
Target/Specificity Peptide comprised of 14 amino acids from the C-terminus of human TICAM1
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsTICAM1 / TRIF Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TICAM1
Synonyms PRVTIRB, TRIF
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Cellular Location Cytoplasmic vesicle, autophagosome. Note=Colocalizes with UBQLN1 in the autophagosome.
Tissue Location Ubiquitously expressed but with higher levels in liver.
Research Areas
Citations (0)

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Background

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

References

Yamamoto M.,et al.J. Immunol. 169:6668-6672(2002).
Oshiumi H.,et al.Nat. Immunol. 4:161-167(2003).
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Matsuda A.,et al.Oncogene 22:3307-3318(2003).
Begum N.A.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11554
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