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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   BARD1 Antibody (aa108-124)   

BARD1 Antibody (aa108-124)

Rabbit Polyclonal Antibody

     
  • IHC - BARD1 Antibody (aa108-124) ALS11565
    Anti-BARD1 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q99728
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 87kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 580
Other Names BRCA1-associated RING domain protein 1, BARD-1, 6.3.2.-, BARD1
Target/Specificity Amino acids 108 to 124 of human BARD1
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsBARD1 Antibody (aa108-124) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BARD1
Function Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Cellular Location Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex
Research Areas
Citations (0)

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Background

Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

References

Wu L.C.,et al.Nat. Genet. 14:430-440(1996).
Thai T.H.,et al.Hum. Mol. Genet. 7:195-202(1998).
Li L.,et al.Cancer Res. 67:11876-11885(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).
Meza J.E.,et al.J. Biol. Chem. 274:5659-5665(1999).

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$ 395.00
Cat# ALS11565
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