|Application ||IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml),|
|Other Names||Growth/differentiation factor 3, GDF-3, GDF3|
|Target/Specificity||Amino acids 35 to 53 of human GDF3|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GDF3 Antibody (aa35-53) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089).|
|Cellular Location||Secreted. Cytoplasm Note=Mainly accumulated in the cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
Lorenz B.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ye M.,et al.Hum. Mol. Genet. 19:287-298(2010).
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