|Application ||IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml),|
|Other Names||Major vault protein, MVP, Lung resistance-related protein, MVP, LRP|
|Target/Specificity||Amino acids 878-893 of human MVP|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MVP / VAULT1 Antibody (aa878-893) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.|
|Cellular Location||Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment|
|Tissue Location||Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Scheffer G.L.,et al.Nat. Med. 1:578-582(1995).
Scheffer G.L.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Lange C.,et al.Biochem. Biophys. Res. Commun. 278:125-133(2000).
Holzmann K.,et al.FEBS Lett. 494:99-104(2001).
Quadroni M.,et al.Submitted (JAN-2005) to UniProtKB.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.