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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MVP / VAULT1 Antibody (aa878-893)   

MVP / VAULT1 Antibody (aa878-893)

Rabbit Polyclonal Antibody

     
  • IHC - MVP / VAULT1 Antibody (aa878-893) ALS11581
    Anti-MVP antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q14764
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 99kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 9961
Other Names Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
Target/Specificity Amino acids 878-893 of human MVP
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsMVP / VAULT1 Antibody (aa878-893) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MVP
Synonyms LRP
Function Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Cellular Location Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665)
Tissue Location Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells
Research Areas
Citations (0)

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Background

Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

References

Scheffer G.L.,et al.Nat. Med. 1:578-582(1995).
Scheffer G.L.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Lange C.,et al.Biochem. Biophys. Res. Commun. 278:125-133(2000).
Holzmann K.,et al.FEBS Lett. 494:99-104(2001).
Quadroni M.,et al.Submitted (JAN-2005) to UniProtKB.

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$ 395.00
Cat# ALS11581
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