|Application ||IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml),|
|Other Names||Major vault protein, MVP, Lung resistance-related protein, MVP, LRP|
|Target/Specificity||Amino acids 878-893 of human MVP|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MVP / VAULT1 Antibody (aa878-893) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.|
|Cellular Location||Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665)|
|Tissue Location||Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells|
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Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Scheffer G.L.,et al.Nat. Med. 1:578-582(1995).
Scheffer G.L.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Lange C.,et al.Biochem. Biophys. Res. Commun. 278:125-133(2000).
Holzmann K.,et al.FEBS Lett. 494:99-104(2001).
Quadroni M.,et al.Submitted (JAN-2005) to UniProtKB.
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