ENL / MLLT1 Antibody (aa538-553)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q03111 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 62kDa |
Dilution | ELISA (1:1000), IHC-P (5 µg/ml), |
Gene ID | 4298 |
---|---|
Other Names | Protein ENL, YEATS domain-containing protein 1, MLLT1, ENL, LTG19, YEATS1 |
Target/Specificity | Amino acids 538 to 553 of human MLLT1 |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | ENL / MLLT1 Antibody (aa538-553) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MLLT1 |
---|---|
Synonyms | ENL, LTG19, YEATS1 |
Function | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
References
Tkachuk D.C.,et al.Cell 71:691-700(1992).
Yamamoto K.,et al.Oncogene 8:2617-2625(1993).
Rubnitz J.E.,et al.Blood 84:1747-1752(1994).
Olsen J.V.,et al.Cell 127:635-648(2006).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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