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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   MAGEA1 / MAGE 1 Antibody (aa158-174)   

MAGEA1 / MAGE 1 Antibody (aa158-174)

Rabbit Polyclonal Antibody

     
  • IHC - MAGEA1 / MAGE 1 Antibody (aa158-174) ALS11594
    Anti-MAGEA1 / MAGE 1 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P43355
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Dilution ELISA (1:1000), IHC-P (2.5 µg/ml),
Additional Information
Other Names Melanoma-associated antigen 1, Antigen MZ2-E, Cancer/testis antigen 1.1, CT1.1, MAGE-1 antigen, MAGEA1, MAGE1, MAGE1A
Target/Specificity Amino acids 158 to 174 of human MAGEA1
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsMAGEA1 / MAGE 1 Antibody (aa158-174) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGEA1
Synonyms MAGE1, MAGE1A
Function May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas EMBL; M77481; AAA03229.1; -; Genomic_DNA EMBL; AY148486; AAN62752.1; -; mRNA EMBL; BT009789; AAP88791.1; -; mRNA EMBL; AK314979; BAG37478.1; -; mRNA EMBL; U82670; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471172; EAW72885.1; -; Genomic_DNA EMBL; BC017555; AAH17555.1; -; mRNA CCDS; CCDS76051.1; - PIR; JC2358; JC2358 RefSeq; NP_004979.3; NM_004988.4 UniGene; Hs.72879; - PDB; 1W72; X-ray; 2.15 A; C/F=161-169 PDB; 3BO8; X-ray; 1.80 A; C=161-169 PDBsum; 1W72; - PDBsum; 3BO8; - ProteinModelPortal; P43355; - SMR; P43355; - BioGrid; 110274; 92 CORUM; P43355; - DIP; DIP-54794N; - IntAct; P43355; 47 MINT; P43355; - STRING; 9606.ENSP00000349085; - iPTMnet; P43355; - PhosphoSitePlus; P43355; - BioMuta; MAGEA1; - DMDM; 1170855; - EPD; P43355; - MaxQB; P43355; - PaxDb; P43355; - PeptideAtlas; P43355; - PRIDE; P43355; - ProteomicsDB; 55617; - DNASU; 4100; - Ensembl; ENST00000356661; ENSP00000349085; ENSG00000198681 GeneID; 4100; - KEGG; hsa:4100; - UCSC; uc004fhf.3; human CTD; 4100; - DisGeNET; 4100; - EuPathDB; HostDB:ENSG00000198681.6; - GeneCards; MAGEA1; - H-InvDB; HIX0017126; - HGNC; HGNC:6796; MAGEA1 HPA; CAB002620; - MIM; 300016; gene neXtProt; NX_P43355; - OpenTargets; ENSG00000198681; - PharmGKB; PA30542; - eggNOG; KOG4562; Eukaryota eggNOG; ENOG4111S70; LUCA GeneTree; ENSGT00760000118824; - HOGENOM; HOG000231161; - HOVERGEN; HBG006315; - InParanoid; P43355; - OMA; VRFFFPS; - OrthoDB; EOG091G0TJ0; - PhylomeDB; P43355; - TreeFam; TF328505; - EvolutionaryTrace; P43355; - GeneWiki; MAGEA1; - GenomeRNAi; 4100; - PRO; PR:P43355; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000198681; - CleanEx; HS_MAGEA1; - Genevisible; P43355; HS GO; GO:0005737; C:cytoplasm; IDA:UniProtKB GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0005886; C:plasma membrane; TAS:ProtInc GO; GO:0042826; F:histone deacetylase binding; IDA:UniProtKB GO; GO:0045746; P:negative regulation of Notch signaling pathway; IDA:UniProtKB GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW InterPro; IPR037445; MAGE InterPro; IPR021072; MAGE_N InterPro; IPR030093; MAGEA1 InterPro; IPR002190; MHD_dom PANTHER; PTHR11736; PTHR11736; 1 PANTHER; PTHR11736:SF49; PTHR11736:SF49; 1 Pfam; PF01454; MAGE; 1 Pfam; PF12440; MAGE_N; 1 SMART; SM01373; MAGE; 1 SMART; SM01392; MAGE_N; 1 PROSITE; PS50838; MAGE; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Tumor antigen CHAIN 1 309 Melanoma-associated antigen 1 /FTId=PRO_0000156701 DOMAIN 102 301 MAGE. {ECO:0000255|PROSITE- ProRule:PRU00127} COMPBIAS 33 36 Poly-Ser MOD_RES 57 57 Phosphoserine VARIANT 32 32 T -> A (probable polymorphism; dbSNP:rs2008160) {ECO:0000269|PubMed:15059299, ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4} /FTId=VAR_004283 VARIANT 63 63 A -> T (in dbSNP:rs2233044) /FTId=VAR_053491 VARIANT 72 72 R -> Q (in dbSNP:rs2008144) /FTId=VAR_011737 VARIANT 278 278 K -> T (in a breast cancer sample; somatic mutation) /FTId=VAR_036581 MUTAGEN 163 163 D->A: Abolishes HLA-A1 binding MUTAGEN 169 169 Y->A: Abolishes HLA-A1 binding SEQUENCE 309 AA; 34342 MW; 544EEB1F9F4E9D33 CRC64; MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG STDPPQSPQG ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA VITKKVADLV GFLLLKYRAR EPVTKAEMLE SVIKNYKHCF PEIFGKASES LQLVFGIDVK EADPTGHSYV LVTCLGLSYD GLLGDNQIMP KTGFLIIVLV MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT QDLVQEKYLE YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA ALREEEEGV
Research Areas
Citations (0)

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Background

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

References

van der Bruggen P.,et al.Science 254:1643-1647(1991).
Ding M.,et al.Biochem. Biophys. Res. Commun. 202:549-555(1994).
Wang L.P.,et al.Zhonghua Gan Zang Bing Za Zhi 12:151-155(2004).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 425.00
Cat# ALS11594
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