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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   MAGEA3 Antibody (aa298-314)   

MAGEA3 Antibody (aa298-314)

Rabbit Polyclonal Antibody

     
  • IHC - MAGEA3 Antibody (aa298-314) ALS11596
    Anti-MAGEA3 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P43357
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 4102
Other Names Melanoma-associated antigen 3, Antigen MZ2-D, Cancer/testis antigen 1.3, CT1.3, MAGE-3 antigen, MAGEA3, MAGE3
Target/Specificity Amino acids 298 to 314 of human MAGEA3
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsMAGEA3 Antibody (aa298-314) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGEA3
Synonyms MAGE3
Function Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Tissue Location Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas
Research Areas
Citations (0)

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Background

Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

References

Gaugler B.,et al.J. Exp. Med. 179:921-930(1994).
Ding M.,et al.Biochem. Biophys. Res. Commun. 202:549-555(1994).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mallon A.-M.,et al.Genome Res. 10:758-775(2000).

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$ 395.00
Cat# ALS11596
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