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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   SHSF1 / SHFM1 Antibody (aa57-70)   

SHSF1 / SHFM1 Antibody (aa57-70)

Rabbit Polyclonal Antibody

     
  • IHC - SHSF1 / SHFM1 Antibody (aa57-70) ALS11601
    Anti-SHFM1 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P60896
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 8kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 7979
Other Names 26S proteasome complex subunit DSS1, Deleted in split hand/split foot protein 1, Split hand/foot deleted protein 1, Split hand/foot malformation type 1 protein, SHFM1, DSS1, SHFDG1
Target/Specificity Amino acids 57 to 70 of human SHFM1
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSHSF1 / SHFM1 Antibody (aa57-70) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHFM1
Synonyms DSS1, SHFDG1
Function Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription- associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.
Tissue Location Expressed in limb bud, craniofacial primordia and skin
Research Areas
Citations (0)

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Background

Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription- associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.

References

Crackower M.A.,et al.Hum. Mol. Genet. 5:571-579(1996).
Hillier L.W.,et al.Nature 424:157-164(2003).
Marston N.J.,et al.Mol. Cell. Biol. 19:4633-4642(1999).
Sone T.,et al.J. Biol. Chem. 279:28807-28816(2004).
Wang X.,et al.Biochemistry 46:3553-3565(2007).

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$ 395.00
Cat# ALS11601
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