|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (20 µg/ml)|
|Other Names||Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, 188.8.131.52, CAMK2A, CAMKA, KIAA0968|
|Target/Specificity||Amino acids surrounding Serine 286 of human CAMK2A|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CAMK2A / CaMKII Alpha Antibody (Thr286) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).|
|Cellular Location||Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse Note=Postsynaptic lipid rafts.|
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Provided below are standard protocols that you may find useful for product applications.
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Li G.Y.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 6:63-70(1999).
Schmutz J.,et al.Nature 431:268-274(2004).
Krapivinsky G.,et al.Neuron 43:563-574(2004).
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