|Application ||WB, IHC-P, E, IP|
|Dilution||IHC-P (10 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Melanoma-associated antigen 1, Antigen MZ2-E, Cancer/testis antigen 1.1, CT1.1, MAGE-1 antigen, MAGEA1, MAGE1, MAGE1A|
|Target/Specificity||Amino acids 245 to 259 of human MAGEA1|
|Reconstitution & Storage||+4°C, avoid freezing|
|Precautions||MAGEA1 / MAGE 1 Antibody (aa245-259) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas|
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May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
van der Bruggen P.,et al.Science 254:1643-1647(1991).
Ding M.,et al.Biochem. Biophys. Res. Commun. 202:549-555(1994).
Wang L.P.,et al.Zhonghua Gan Zang Bing Za Zhi 12:151-155(2004).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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