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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | O14508 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 22kDa |
| Dilution | IHC-P (20 µg/ml), IP (0.3-0.5 µg/10E6 cells), WB (0.5-2 µg/ml) |
| Gene ID | 8835 |
|---|---|
| Other Names | Suppressor of cytokine signaling 2, SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, CIS2, SSI2, STATI2 |
| Target/Specificity | Peptide from human SOCS2 |
| Reconstitution & Storage | +4°C, avoid freezing |
| Precautions | SOCS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOCS2 |
|---|---|
| Synonyms | CIS2, SSI2, STATI2 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Tissue Location | High expression in heart, placenta, lung, kidney and prostate |
| Volume | 250 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
References
Minamoto S.,et al.Biochem. Biophys. Res. Commun. 237:79-83(1997).
Masuhara M.,et al.Biochem. Biophys. Res. Commun. 239:439-446(1997).
Tu Q.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
Dey B.R.,et al.J. Biol. Chem. 273:24095-24101(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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