SOCS2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, IP |
---|---|
Primary Accession | O14508 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 22kDa |
Dilution | IHC-P (20 µg/ml), IP (0.3-0.5 µg/10E6 cells), WB (0.5-2 µg/ml) |
Gene ID | 8835 |
---|---|
Other Names | Suppressor of cytokine signaling 2, SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, CIS2, SSI2, STATI2 |
Target/Specificity | Peptide from human SOCS2 |
Reconstitution & Storage | +4°C, avoid freezing |
Precautions | SOCS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SOCS2 |
---|---|
Synonyms | CIS2, SSI2, STATI2 |
Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
Tissue Location | High expression in heart, placenta, lung, kidney and prostate |
Volume | 250 µl |

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abgent.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
References
Minamoto S.,et al.Biochem. Biophys. Res. Commun. 237:79-83(1997).
Masuhara M.,et al.Biochem. Biophys. Res. Commun. 239:439-446(1997).
Tu Q.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
Dey B.R.,et al.J. Biol. Chem. 273:24095-24101(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.