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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SOCS4 Antibody (C-Terminus)   

SOCS4 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SOCS4 Antibody (C-Terminus) ALS11642
    Anti-SOCS4 antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q8WXH5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 51kDa
Dilution IHC-P (10 µg/ml), IP (0.3-0.5 µg/10E6 cells), WB (0.5-2 µg/ml)
Additional Information
Gene ID 122809
Other Names Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7
Target/Specificity Peptide from the C-terminus of human SOCS4
Reconstitution & Storage +4°C, avoid freezing
PrecautionsSOCS4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOCS4
Synonyms SOCS7
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
Volume 250 µl
Research Areas
Citations (0)

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Background

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

References

Hilton D.J.,et al.Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
Kario E.,et al.J. Biol. Chem. 280:7038-7048(2005).
Bullock A.N.,et al.Structure 15:1493-1504(2007).

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$ 395.00
Cat# ALS11642
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