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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   WT1 / Wilms Tumor 1 Antibody (C-Terminus)   

WT1 / Wilms Tumor 1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - WT1 / Wilms Tumor 1 Antibody (C-Terminus) ALS11647
    Anti-WT1 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P19544
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 7490
Other Names Wilms tumor protein, WT33, WT1
Target/Specificity Peptide from the C-terminus of human WT1
Reconstitution & Storage +4°C, avoid freezing
PrecautionsWT1 / Wilms Tumor 1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WT1
Function Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).
Cellular Location Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190) Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:15520190} Isoform 4: Nucleus, nucleoplasm
Tissue Location Expressed in the kidney and a subset of hematopoietic cells
Volume 250 µl
Research Areas
Citations (0)

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Background

Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

References

Gessler M.,et al.Nature 343:774-778(1990).
Haber D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:9618-9622(1991).
Gessler M.,et al.Genomics 12:807-813(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).

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Discontinued
Cat# ALS11647
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