|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (1-2 µg/ml), WB (1-2 µg/ml),|
|Other Names||Nitric oxide synthase, inducible, 184.108.40.206, Hepatocyte NOS, HEP-NOS, Inducible NO synthase, Inducible NOS, iNOS, NOS type II, Peptidyl-cysteine S-nitrosylase NOS2, NOS2, NOS2A|
|Target/Specificity||Peptide from the C-terminus of mouse NOS2A|
|Reconstitution & Storage||+4°C, avoid freezing|
|Precautions||NOS2 / iNOS Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).|
|Tissue Location||Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets|
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Provided below are standard protocols that you may find useful for product applications.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Sherman P.A.,et al.Biochemistry 32:11600-11605(1993).
Geller D.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993).
Charles I.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993).
Maier R.,et al.Biochim. Biophys. Acta 1208:145-150(1994).
Park C.S.,et al.Biochem. Biophys. Res. Commun. 205:85-91(1994).
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