BCL2L11 / BIM Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
---|---|
Primary Accession | O43521 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 22kDa |
Dilution | IHC-P (5 µg/ml), WB (2.5 µg/ml), |
Gene ID | 10018 |
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Other Names | Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, BIM |
Target/Specificity | peptide corresponding to amino acids near the center of human Bim The sequence is identical to that of mouse and rat |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | BCL2L11 / BIM Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BCL2L11 |
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Synonyms | BIM |
Function | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase- mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. |
Cellular Location | Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. [Isoform BimL]: Mitochondrion. [Isoform Bim-alpha1]: Mitochondrion. |
Tissue Location | Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. |
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Background
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
References
O'Connor L.,et al.EMBO J. 17:384-395(1998).
Mami U.,et al.FEBS Lett. 509:135-141(2001).
Liu J.-W.,et al.Cancer Res. 62:2976-2981(2002).
Marani M.,et al.Mol. Cell. Biol. 22:3577-3589(2002).
Chen J.Z.,et al.Int. J. Biochem. Cell Biol. 36:1554-1561(2004).
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