|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (2-4 µg/ml),|
|Other Names||Radiation-inducible immediate-early gene IEX-1, Differentiation-dependent gene 2 protein, Protein DIF-2, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein PRG1, IER3, DIF2, IEX1, PRG1|
|Target/Specificity||a 24 amino acid peptide near the center of human IEX1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||IER3 / IEX-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DIF2, IEX1, PRG1|
|Function||May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
Kondratyev A.D.,et al.Cancer Res. 56:1498-1502(1996).
Schaefer H.,et al.Cancer Res. 56:2641-2648(1996).
Pietzsch A.,et al.Biochem. Biophys. Res. Commun. 235:4-9(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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