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IER3 / IEX-1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - IER3 / IEX-1 Antibody (Internal) ALS11688
    Anti-IEX1 antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P46695
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 17kDa
Dilution IHC-P (5 µg/ml), WB (2-4 µg/ml),
Additional Information
Gene ID 8870
Other Names Radiation-inducible immediate-early gene IEX-1, Differentiation-dependent gene 2 protein, Protein DIF-2, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein PRG1, IER3, DIF2, IEX1, PRG1
Target/Specificity a 24 amino acid peptide near the center of human IEX1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsIER3 / IEX-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IER3
Synonyms DIF2, IEX1, PRG1
Function May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
Cellular Location Membrane; Single-pass type II membrane protein
Research Areas
Citations (0)

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Background

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

References

Kondratyev A.D.,et al.Cancer Res. 56:1498-1502(1996).
Schaefer H.,et al.Cancer Res. 56:2641-2648(1996).
Pietzsch A.,et al.Biochem. Biophys. Res. Commun. 235:4-9(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11688
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