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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL21 Antibody (Internal)   

IL21 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - IL21 Antibody (Internal) ALS11691
    Anti-IL21 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9HBE4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 18kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 59067
Other Names Interleukin-21, IL-21, Za11, IL21
Target/Specificity synthetic peptide corresponding to 15 amino acids near the center of human IL-21 precursor
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsIL21 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL21
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Cellular Location Secreted.
Tissue Location Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes
Research Areas
Citations (0)

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Background

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

References

Parrish-Novak J.,et al.Nature 408:57-63(2000).
Rahman M.,et al.FEBS Lett. 581:4001-4009(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).
Strengell M.,et al.J. Leukoc. Biol. 76:416-422(2004).
Sivakumar P.V.,et al.Immunology 112:177-182(2004).

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$ 395.00
Cat# ALS11691
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