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IL21 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - IL21 Antibody (Internal) ALS11691
    Anti-IL21 antibody IHC of human spleen.
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  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9HBE4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 18kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 59067
Other Names Interleukin-21, IL-21, Za11, IL21
Target/Specificity synthetic peptide corresponding to 15 amino acids near the center of human IL-21 precursor
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsIL21 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL21 (HGNC:6005)
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes
Research Areas
Citations (0)
citation

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Background

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

References

Parrish-Novak J.,et al.Nature 408:57-63(2000).
Rahman M.,et al.FEBS Lett. 581:4001-4009(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).
Strengell M.,et al.J. Leukoc. Biol. 76:416-422(2004).
Sivakumar P.V.,et al.Immunology 112:177-182(2004).

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$ 467.50
Cat# ALS11691
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