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IRS1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | P35568 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 132kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 3667 |
|---|---|
| Other Names | Insulin receptor substrate 1, IRS-1, IRS1 |
| Target/Specificity | 16 amino acid peptide from near the center of human IRS-1 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | IRS1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IRS1 |
|---|---|
| Function | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
References
Araki E.,et al.Diabetes 42:1041-1054(1993).
Nishiyama M.,et al.Biochem. Biophys. Res. Commun. 183:280-285(1992).
Smith L.K.,et al.Biochem. Biophys. Res. Commun. 196:767-772(1993).
Craparo A.,et al.J. Biol. Chem. 270:15639-15643(1995).
He W.,et al.J. Biol. Chem. 270:23258-23262(1995).
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