|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88 adapter-like protein, MyD88-2, TIRAP, MAL|
|Target/Specificity||peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TIRAP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.|
|Cellular Location||Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane|
|Tissue Location||Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain|
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Provided below are standard protocols that you may find useful for product applications.
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Fitzgerald K.A.,et al.Nature 413:78-83(2001).
Horng T.,et al.Nat. Immunol. 2:835-841(2001).
Kirk P.B.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Hardy M.P.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
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