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TIRAP Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P58753 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24kDa |
| Dilution | IHC-P (5 µg/ml), WB (0.5-2 µg/ml), |
| Gene ID | 114609 |
|---|---|
| Other Names | Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88 adapter-like protein, MyD88-2, TIRAP, MAL |
| Target/Specificity | peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | TIRAP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TIRAP |
|---|---|
| Synonyms | MAL |
| Function | Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6). |
| Cellular Location | Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane |
| Tissue Location | Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
References
Fitzgerald K.A.,et al.Nature 413:78-83(2001).
Horng T.,et al.Nat. Immunol. 2:835-841(2001).
Kirk P.B.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Hardy M.P.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
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