TLR5 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
---|---|
Primary Accession | O60602 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 98kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 7100 |
---|---|
Other Names | Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3, TLR5, TIL3 |
Target/Specificity | peptide corresponding to 15 amino acids near the carboxy terminus of human TLR5 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | TLR5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TLR5 |
---|---|
Synonyms | TIL3 |
Function | Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF- kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
References
Chaudhary P.M.,et al.Blood 91:4020-4027(1998).
Seya T.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Wlasiuk G.,et al.Mol. Biol. Evol. 26:937-949(2009).
Georgel P.,et al.PLoS ONE 4:E7803-E7803(2009).
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