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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNFSF11 / RANKL / TRANCE Antibody (Internal)   

TNFSF11 / RANKL / TRANCE Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - TNFSF11 / RANKL / TRANCE Antibody (Internal) ALS11732
    Anti-RANKL antibody IHC of human breast.
  • IHC - TNFSF11 / RANKL / TRANCE Antibody (Internal) ALS11732
    Anti-RANKL antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O14788
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Dilution IHC-P (5 µg/ml), WB (0.25-0.5 µg/ml),
Additional Information
Gene ID 8600
Other Names Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, RANKL, TNF-related activation-induced cytokine, TRANCE, CD254, Tumor necrosis factor ligand superfamily member 11, membrane form, Tumor necrosis factor ligand superfamily member 11, soluble form, TNFSF11, OPGL, RANKL, TRANCE
Target/Specificity 14 amino acid peptide from near the center of human sRANK-L
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsTNFSF11 / RANKL / TRANCE Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFSF11
Synonyms OPGL, RANKL, TRANCE
Function Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type II membrane protein Isoform 2: Cytoplasm.
Tissue Location Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid
Research Areas
Citations (0)

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Background

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

References

Anderson D.M.,et al.Nature 390:175-179(1997).
Lacey D.L.,et al.Cell 93:165-176(1998).
Ikeda T.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Nagai M.,et al.Biochem. Biophys. Res. Commun. 269:532-536(2000).
Wong B.R.,et al.J. Biol. Chem. 272:25190-25194(1997).

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$ 395.00
Cat# ALS11732
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