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>   home   >   Products   >   Primary Antibodies   >   MRE11A / MRE11 Antibody (aa68-706)   

MRE11A / MRE11 Antibody (aa68-706)

Rabbit Polyclonal Antibody

     
  • IHC - MRE11A / MRE11 Antibody (aa68-706) ALS11749
    Anti-MRE11A / MRE11 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P49959
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 81kDa
Dilution ELISA (1:10000-1:50000), IHC-P (5 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 4361
Other Names Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11A, HNGS1, MRE11
Target/Specificity MRE11A / MRE11
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsMRE11A / MRE11 Antibody (aa68-706) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRE11A
Synonyms HNGS1, MRE11
Function Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t- loop formation (PubMed:10888888).
Cellular Location Nucleus. Chromosome, telomere. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents
Citations (0)

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Background

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

References

Petrini J.H.J.,et al.Genomics 29:80-86(1995).
Petrini J.H.J.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Chamankhah M.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Paull T.T.,et al.Mol. Cell 1:969-979(1998).
Pitts S.A.,et al.Hum. Mol. Genet. 10:1155-1162(2001).

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$ 395.00
Cat# ALS11749
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