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>   home   >   Products   >   Primary Antibodies   >   EIF2S1 Antibody (Ser51)   

EIF2S1 Antibody (Ser51)

Rabbit Polyclonal Antibody

     
  • WB - EIF2S1 Antibody (Ser51) ALS11764
    Western blot of extracts from 3T3, HeLa and C6 cells using eIF2a(Ab-51) antibody.
  • IF - EIF2S1 Antibody (Ser51) ALS11764
    Immunofluorescence staining of methanol-fixed HeLa cells using eIF2a(Ab-51) antibody.
  • IHC - EIF2S1 Antibody (Ser51) ALS11764
    Anti-EIF2S1 antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P05198
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 36kDa
Dilution IHC-P (10 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 1965
Other Names Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, EIF2S1, EIF2A
Target/Specificity Amino acids surrounding Ser 51 of human EIF2A
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsEIF2S1 Antibody (Ser51) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF2S1
Synonyms EIF2A
Function Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Cellular Location Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity).
Citations (0)

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Background

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

References

Ernst H.,et al.J. Biol. Chem. 262:1206-1212(1987).
Langland J.O.,et al.Virology 324:419-429(2004).
Paytubi S.,et al.Biochem. J. 409:223-231(2008).
Montero H.,et al.J. Virol. 82:1496-1504(2008).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).

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$ 395.00
Cat# ALS11764
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