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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSP90AB1 / HSP90 Alpha B1 Antibody (Ser254)   

HSP90AB1 / HSP90 Alpha B1 Antibody (Ser254)

Rabbit Polyclonal Antibody

     
  • WB - HSP90AB1 / HSP90 Alpha B1 Antibody (Ser254) ALS11771
    Western blot of extracts from HeLa and A2780 cells using HSP90B(Ab-254) antibody.
  • IF - HSP90AB1 / HSP90 Alpha B1 Antibody (Ser254) ALS11771
    Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining using...
  • IHC - HSP90AB1 / HSP90 Alpha B1 Antibody (Ser254) ALS11771
    Anti-HSP90AB1 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P08238
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 83kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3326
Other Names Heat shock protein HSP 90-beta, HSP 90, Heat shock 84 kDa, HSP 84, HSP84, HSP90AB1, HSP90B, HSPC2, HSPCB
Target/Specificity Amino acids surrounding Ser 254 of human HSP90AB1
Reconstitution & Storage Long term: -70°C; Short term: -20°C
PrecautionsHSP90AB1 / HSP90 Alpha B1 Antibody (Ser254) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSP90AB1
Synonyms HSP90B, HSPC2, HSPCB
Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)

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Background

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

References

Rebbe N.F.,et al.Gene 53:235-245(1987).
Rebbe N.F.,et al.J. Biol. Chem. 264:15006-15011(1989).
Hoffmann T.,et al.Gene 74:491-501(1988).
Lu L.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).

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$ 395.00
Cat# ALS11771
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