|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Non-receptor tyrosine-protein kinase TYK2, 22.214.171.124, TYK2|
|Target/Specificity||Amino acids surrounding Tyr 1054 of human TYK2|
|Reconstitution & Storage||For long term, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TYK2 Antibody (Tyr1054) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.|
|Tissue Location||Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines|
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Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Firmbach-Kraft I.,et al.Oncogene 5:1329-1336(1990).
Velazquez L.,et al.Cell 70:313-322(1992).
Krolewski J.J.,et al.Oncogene 5:277-282(1990).
Partanen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990).
Colamonici O.,et al.Mol. Cell. Biol. 14:8133-8142(1994).
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