|Application ||WB, IHC-P, ICC|
|Reactivity||Human, Rat, Bovine|
|Other Names||Arachidonate 5-lipoxygenase, 5-LO, 5-lipoxygenase, 220.127.116.11, ALOX5, LOG5|
|Target/Specificity||Human and rat amino acids 130-149 (QHRRKELETRQKQYRWMEWN); The sequence is 95% homologous to 5-LO from mouse and hamster|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ALOX5 / 5-Lipoxygenase Antibody (aa130-149) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.|
|Cellular Location||Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Dixon R.A.F.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:416-420(1988).
Matsumoto T.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:26-30(1988).
Matsumoto T.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3406-3406(1988).
Matsumoto T.,et al.Adv. Prostaglandin Thromboxane Leukotriene Res. 19:466-469(1989).
Boudreau L.H.,et al.FASEB J. 25:1097-1105(2011).
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