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GSTP1 / GST Pi Antibody (clone 3F2C2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E, IHC-Fr |
|---|---|
| Primary Accession | P09211 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3F2C2 |
| Calculated MW | 23kDa |
| Dilution | ELISA (1:10000), IHC-Fr (1:500-1:2000), IHC-P (1:500-1:2000), WB (1:500-1:2000) , |
| Gene ID | 2950 |
|---|---|
| Other Names | Glutathione S-transferase P, 2.5.1.18, GST class-pi, GSTP1-1, GSTP1, FAEES3, GST3 |
| Target/Specificity | Ni-NTA purified truncated recombinant GSTP1 expressed in E. Coli strain BL21 (DE3) |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GSTP1 / GST Pi Antibody (clone 3F2C2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSTP1 (HGNC:4638) |
|---|---|
| Synonyms | FAEES3, GST3 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. |
| Cellular Location | Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
References
Kano T.,et al.Cancer Res. 47:5626-5630(1987).
Cowell I.G.,et al.Biochem. J. 255:79-83(1988).
Morrow C.S.,et al.Gene 75:3-11(1989).
Moscow J.A.,et al.Cancer Res. 49:1422-1428(1989).
Bora P.S.,et al.Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
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