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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD36 Antibody (aa99-114)   

CD36 Antibody (aa99-114)

Rabbit Polyclonal Antibody

     
  • WB - CD36 Antibody (aa99-114) ALS11799
    Bands located at 88 kD (glycosylated) and 54kD (non-glycosylated).
  • IHC - CD36 Antibody (aa99-114) ALS11799
    Anti-CD36 antibody IHC of mouse small intestine.
  • IHC - CD36 Antibody (aa99-114) ALS11799
    Anti-CD36 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P16671
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 53kDa
Dilution IHC-P (1:200)
Additional Information
Gene ID 948
Other Names Platelet glycoprotein 4, Fatty acid translocase, FAT, Glycoprotein IIIb, GPIIIB, Leukocyte differentiation antigen CD36, PAS IV, PAS-4, Platelet collagen receptor, Platelet glycoprotein IV, GPIV, Thrombospondin receptor, CD36, CD36, GP3B, GP4
Target/Specificity human CD36 amino acids 99-114 (AKENVTQDAEDNTVSF)
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsCD36 Antibody (aa99-114) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD36
Synonyms GP3B, GP4
Function Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis.
Volume 1 ea
Research Areas
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Background

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

References

Oquendo P.,et al.Cell 58:95-101(1989).
Sugimoto Y.,et al.Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
Taylor K.T.,et al.Gene 133:205-212(1993).
Wyler B.,et al.Thromb. Haemost. 70:500-505(1993).
Armesilla A.L.,et al.J. Biol. Chem. 269:18985-18991(1994).

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$ 395.00
Cat# ALS11799
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