|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Monkey, Pig, Horse, Dog|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR|
|Target/Specificity||human CB1 receptor sequence amino acids 461-472 (MSVSTDTSAEAL)|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||CNR1 / CB1 Antibody (aa461-472) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Gerard C.,et al.Nucleic Acids Res. 18:7142-7142(1990).
Gerard C.,et al.Biochem. J. 279:129-134(1991).
Shire D.,et al.J. Biol. Chem. 270:3726-3731(1995).
Ryberg E.,et al.FEBS Lett. 579:259-264(2005).
Kathmann M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
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