|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||ELL-associated factor 2, Testosterone-regulated apoptosis inducer and tumor suppressor protein, EAF2, TRAITS|
|Target/Specificity||human U19 amino acids 5-16 (AGFSHLDRRERV)|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||EAF2 / U19 Antibody (aa5-16) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.|
|Cellular Location||Nucleus speckle|
|Tissue Location||Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes|
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Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Simone F.,et al.Blood 101:2355-2362(2003).
Xiao W.,et al.Cancer Res. 63:4698-4704(2003).
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Kong S.E.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:10094-10098(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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