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LTA4H / LTA4 Antibody

Rabbit Polyclonal Antibody

     
  • WB - LTA4H / LTA4 Antibody ALS11803
    Western blot of LTA4H / LTA4 antibody ALS11803.
    detail
  • IHC - LTA4H / LTA4 Antibody ALS11803
    Anti-LTA4H antibody IHC of human small intestine.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P09960
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 69kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 4048
Other Names Leukotriene A-4 hydrolase, LTA-4 hydrolase, 3.3.2.6, Leukotriene A(4) hydrolase, LTA4H, LTA4
Target/Specificity Recombinant human LTA4 hydrolase1,2
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsLTA4H / LTA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LTA4H
Synonyms LTA4
Function Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti- inflammatory and pro-resolving actions (PubMed:21206090).
Cellular Location Cytoplasm.
Tissue Location Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts
Volume 1 ea
Research Areas
Citations (0)
citation

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Background

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

References

Minami M.,et al.J. Biol. Chem. 262:13873-13876(1987).
Funk C.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6677-6681(1987).
Mancini J.A.,et al.Eur. J. Biochem. 231:65-71(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS11803
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