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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLA2G6 / IPLA2 Antibody (aa557-576)   

PLA2G6 / IPLA2 Antibody (aa557-576)

Rabbit Polyclonal Antibody

     
  • IHC - PLA2G6 / IPLA2 Antibody (aa557-576) ALS11806
    Anti-PLA2G6 antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O60733
Reactivity Human, Hamster
Host Rabbit
Clonality Polyclonal
Calculated MW 90kDa
Dilution IHC-P (1:200-1:400)
Additional Information
Gene ID 8398
Other Names 85/88 kDa calcium-independent phospholipase A2, CaI-PLA2, 3.1.1.4, Group VI phospholipase A2, GVI PLA2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, iPLA2-beta, Patatin-like phospholipase domain-containing protein 9, PNPLA9, PLA2G6, PLPLA9
Target/Specificity Hamster iPLA2 amino acids 557-576 (PRFNQNINLKPPTQPADQLV)1,2,3
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsPLA2G6 / IPLA2 Antibody (aa557-576) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLA2G6
Synonyms PLPLA9
Function Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.
Cellular Location Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes
Tissue Location Four different transcripts were found to be expressed in a distinct tissue distribution
Volume 1 ea
Research Areas
Citations (0)

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Background

Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.

References

Larsson P.K.A.,et al.J. Biol. Chem. 273:207-214(1998).
Ma Z.,et al.J. Biol. Chem. 274:9607-9616(1999).
Larsson Forsell P.K.A.,et al.Eur. J. Biochem. 262:575-585(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).

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Discontinued
Cat# ALS11806
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