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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTGS2 / COX2 / COX-2 Antibody (aa578-596)   

PTGS2 / COX2 / COX-2 Antibody (aa578-596)

Goat Polyclonal Antibody

     
  • IHC - PTGS2 / COX2 / COX-2 Antibody (aa578-596) ALS11809
    Anti-COX-2 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession P35354
Reactivity Human, Mouse, Rat, Sheep
Host Goat
Clonality Polyclonal
Calculated MW 69kDa
Dilution ICC (1-2 µg/ml), IHC-P (5 µg/ml), WB (2 µg/ml)
Additional Information
Gene ID 5743
Other Names Prostaglandin G/H synthase 2, 1.14.99.1, Cyclooxygenase-2, COX-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, Prostaglandin-endoperoxide synthase 2, PTGS2, COX2
Target/Specificity human COX-2 amino acids 578-596
Reconstitution & Storage Long term: -20°C; Short term: -20°C
PrecautionsPTGS2 / COX2 / COX-2 Antibody (aa578-596) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTGS2
Synonyms COX2
Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Cellular Location Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein
Research Areas
Citations (0)

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Background

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

References

Jones D.A.,et al.J. Biol. Chem. 268:9049-9054(1993).
Hla T.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7384-7388(1992).
Kosaka T.,et al.Eur. J. Biochem. 221:889-897(1994).
Appleby S.B.,et al.Biochem. J. 302:723-727(1994).
Sharma S.V.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS11809
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