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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLA2G2A / SPLA2 Antibody   

PLA2G2A / SPLA2 Antibody

Mouse Monoclonal Antibody

     
  • IHC - PLA2G2A / SPLA2 Antibody ALS11811
    Anti-PLA2G2A antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P14555
Reactivity Human
Host Mouse
Clonality Monoclonal
Calculated MW 16kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 5320
Other Names Phospholipase A2, membrane associated, 3.1.1.4, GIIC sPLA2, Group IIA phospholipase A2, Non-pancreatic secretory phospholipase A2, NPS-PLA2, Phosphatidylcholine 2-acylhydrolase 2A, PLA2G2A, PLA2B, PLA2L, RASF-A
Target/Specificity Recombinant human sPLA2 Type IIA
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsPLA2G2A / SPLA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLA2G2A
Synonyms PLA2B, PLA2L, RASF-A
Function Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).
Cellular Location Cell membrane; Peripheral membrane protein. Secreted
Volume Array
Research Areas
Citations (0)

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Background

Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.

References

Seilhamer J.J.,et al.J. Biol. Chem. 264:5335-5338(1989).
Kramer R.M.,et al.J. Biol. Chem. 264:5768-5775(1989).
Kramer R.M.,et al.Adv. Exp. Med. Biol. 275:35-53(1990).
Liang N.S.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS11811
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