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CD59 Antibody (clone 1F5)

Mouse Monoclonal Antibody

     
  • IHC - CD59 Antibody (clone 1F5) ALS11814
    Anti-CD59 antibody IHC of human placenta.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, Flo
Primary Accession P13987
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1F5
Calculated MW 14kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 966
Other Names CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin, CD59, CD59, MIC11, MIN1, MIN2, MIN3, MSK21
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsCD59 Antibody (clone 1F5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD59
Synonyms MIC11, MIN1, MIN2, MIN3, MSK21
Function Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues
Research Areas
Citations (0)
citation

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Background

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

References

Davies A.,et al.J. Exp. Med. 170:637-654(1989).
Philbrick W.M.,et al.Eur. J. Immunol. 20:87-92(1990).
Okada H.,et al.Biochem. Biophys. Res. Commun. 162:1553-1559(1989).
Sugita Y.,et al.J. Biochem. 106:555-557(1989).
Sawada R.,et al.DNA Cell Biol. 9:213-220(1990).

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Discontinued
Cat# ALS11814
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