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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   STAT2 Antibody (C-Terminus)   

STAT2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - STAT2 Antibody (C-Terminus) ALS11831
    Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed...
  • IHC - STAT2 Antibody (C-Terminus) ALS11831
    Anti-STAT2 antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P52630
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 98kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 6773
Other Names Signal transducer and activator of transcription 2, p113, STAT2
Target/Specificity Peptide mapping to the carboxy terminus of human STAT2
Reconstitution & Storage +4°C, avoid freezing
PrecautionsSTAT2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT2
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta
Research Areas
Citations (0)

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Background

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

References

Fu X.-Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992).
Yan R.,et al.Nucleic Acids Res. 23:459-463(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Fu X.Y.,et al.Cell 70:323-335(1992).

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$ 395.00
Cat# ALS11831
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