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>   home   >   Products   >   Primary Antibodies   >   LIG3 / DNA Ligase III Antibody (clone 4C11)   

LIG3 / DNA Ligase III Antibody (clone 4C11)

Mouse Monoclonal Antibody

     
  • IHC - LIG3 / DNA Ligase III Antibody (clone 4C11) ALS11862
    Anti-LIG3 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P49916
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4C11
Calculated MW 113kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3980
Other Names DNA ligase 3, 6.5.1.1, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3, LIG3
Target/Specificity Recombinant full-length human DNA Ligase III-b
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsLIG3 / DNA Ligase III Antibody (clone 4C11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIG3
Function Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Cellular Location Isoform 1: Mitochondrion Note=Contains an N-terminal mitochondrial transit peptide Isoform 3: Nucleus. Note=Lacks the N-terminal mitochondrial transit peptide.
Tissue Location Testis, thymus, prostate and heart.
Citations (0)

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Background

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).

References

Wei Y.-F.,et al.Mol. Cell. Biol. 15:3206-3216(1995).
Chen J.,et al.Mol. Cell. Biol. 15:5412-5422(1995).
Wang W.,et al.Nucleic Acids Res. 39:44-58(2011).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11862
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