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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   HEC1 / NDC80 Antibody (aa56-642, clone 9G3.23)   

HEC1 / NDC80 Antibody (aa56-642, clone 9G3.23)

Mouse Monoclonal Antibody

     
  • IHC - HEC1 / NDC80 Antibody (aa56-642, clone 9G3.23) ALS11865
    Anti-NDC80 / HEC1 antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IP
Primary Accession O14777
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 9G3.23
Calculated MW 74kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 10403
Other Names Kinetochore protein NDC80 homolog, Highly expressed in cancer protein, Kinetochore protein Hec1, HsHec1, Kinetochore-associated protein 2, Retinoblastoma-associated protein HEC, NDC80, HEC, HEC1, KNTC2
Target/Specificity Human HEC1 protein consisting of amino acids 56-642.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsHEC1 / NDC80 Antibody (aa56-642, clone 9G3.23) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDC80
Synonyms HEC, HEC1, KNTC2
Function Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore
Research Areas
Citations (0)

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Background

Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

References

Chen Y.,et al.Mol. Cell. Biol. 17:6049-6056(1997).
Chen Y.,et al.J. Biol. Chem. 272:24081-24087(1997).
Zheng L.,et al.Mol. Cell. Biol. 19:5417-5428(1999).
Zheng L.,et al.Mol. Cell. Biol. 20:3529-3537(2000).
Chen Y.,et al.J. Biol. Chem. 277:49408-49416(2002).

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$ 395.00
Cat# ALS11865
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