|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, 22.214.171.124, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MAP2K2, MEK2, MKK2, PRKMK2|
|Target/Specificity||Phosphopetide derived from human MEK2 around the phosphorylation site of threonine 394 (P-G-TP-P-T)|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MAP2K2 / MKK2 / MEK2 Antibody (phospho-Thr394) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MEK2, MKK2, PRKMK2|
|Function||Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane localization is probably regulated by its interaction with KSR1|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
Zheng C.-F.,et al.J. Biol. Chem. 268:11435-11439(1993).
Bienvenut W.V.,et al.Submitted (DEC-2008) to UniProtKB.
Mittal R.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:18574-18579(2006).
Duesbery N.S.,et al.Science 280:734-737(1998).
Vitale G.,et al.Biochem. J. 352:739-745(2000).
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