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NET1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q7Z628 |
| Reactivity | Human, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 68kDa |
| Dilution | ELISA (1:16000), IHC-P (2.5 µg/ml), |
| Gene ID | 10276 |
|---|---|
| Other Names | Neuroepithelial cell-transforming gene 1 protein, Proto-oncogene p65 Net1, Rho guanine nucleotide exchange factor 8, NET1, ARHGEF8 |
| Target/Specificity | Human NET1. This antibody is expected to recognize both reported isoforms (NP_001040625.1 and NP_005854.2). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | NET1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NET1 |
|---|---|
| Synonyms | ARHGEF8 |
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
References
Chan A.M.-L.,et al.Oncogene 12:1259-1266(1996).
Shen X.,et al.J. Biol. Chem. 276:15362-15368(2001).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Srougi M.C.,et al.PLoS ONE 6:E17108-E17108(2011).
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