|Application ||IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (1.25 µg/ml),|
|Other Names||E3 ubiquitin-protein ligase RNF213, 6.3.2.-, ALK lymphoma oligomerization partner on chromosome 17, Mysterin, RING finger protein 213, RNF213, ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||RNF213 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547).|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Widely expressed (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity.
Liu W.,et al.PLoS ONE 6:E22542-E22542(2011).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Cools J.,et al.Genes Chromosomes Cancer 34:354-362(2002).
Nagase T.,et al.DNA Res. 7:273-281(2000).
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