|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Horse, Dog|
|Dilution||ELISA (1:2000), IHC-P (5 µg/ml),|
|Other Names||Sorbin and SH3 domain-containing protein 1, Ponsin, SH3 domain protein 5, SH3P12, c-Cbl-associated protein, CAP, SORBS1 (HGNC:14565)|
|Target/Specificity||Human SORBS1. This antibody is expected to recognise all 7 reported isoforms (NP_006425.2, NP_056200.1, NP_001030126.1, NP_001030127.1, NP_001030128.1, NP_079267.1 and NP_001030129.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SORBS1 / Ponsin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).|
|Cellular Location||Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion Nucleus. Nucleus matrix Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.|
|Tissue Location||Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.|
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Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
Lin W.-H.,et al.Genomics 74:12-20(2001).
Lebre A.-S.,et al.Hum. Mol. Genet. 10:1201-1213(2001).
Lin W.-H.,et al.Hum. Mol. Genet. 10:1753-1760(2001).
Vandenbroere I.,et al.Biochem. Biophys. Res. Commun. 300:494-500(2003).
Gehmlich K.,et al.J. Mol. Biol. 369:665-682(2007).
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