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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TMBIM6 / Bax Inhibitor 1 Antibody (clone 20F430)   

TMBIM6 / Bax Inhibitor 1 Antibody (clone 20F430)

Mouse Monoclonal Antibody

     
  • IHC - TMBIM6 / Bax Inhibitor 1 Antibody (clone 20F430) ALS11908
    Anti-TMBIM6 / Bax Inhibitor 1 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P55061
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 20F430
Calculated MW 27kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 7009
Other Names Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein, Transmembrane BAX inhibitor motif-containing protein 6, TMBIM6, BI1, TEGT
Target/Specificity A mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human Bax Inhibitor 1. Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsTMBIM6 / Bax Inhibitor 1 Antibody (clone 20F430) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMBIM6
Synonyms BI1, TEGT
Function Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi- pass membrane protein
Tissue Location Highly abundant in testis.
Research Areas
Citations (0)

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Background

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel.

References

Walter L.,et al.Genomics 28:301-304(1995).
Cowling R.T.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Kim J.-H.,et al.Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 395.00
Cat# ALS11908
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