TMBIM6 / Bax Inhibitor 1 Antibody (clone 20F430)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P55061 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 20F430 |
Calculated MW | 27kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 7009 |
---|---|
Other Names | Bax inhibitor 1, BI-1, Testis-enhanced gene transcript protein, Transmembrane BAX inhibitor motif-containing protein 6, TMBIM6, BI1, TEGT |
Target/Specificity | A mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human Bax Inhibitor 1. Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1. |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | TMBIM6 / Bax Inhibitor 1 Antibody (clone 20F430) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TMBIM6 |
---|---|
Synonyms | BI1, TEGT |
Function | Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Highly abundant in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel.
References
Walter L.,et al.Genomics 28:301-304(1995).
Cowling R.T.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Kim J.-H.,et al.Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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